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Education
- B.S.
In Pharmacy, Zhejiang University College
of Pharmacy, Hangzhou,
PRC
- M.S.
In Pharmacology, Zhejiang University College
of Pharmacy, Hangzhou,
PRC
- Ph.D.
In Pharmacology & Toxicology, University
of Arizona, Tucson, USA
Teaching
Research
Interests
- Toxicology of blood-brain barrier and blood-CSF
barrier.
- Neurotoxicology of heavy metals (lead,
manganese, iron and aluminum): transport, homeostasis in the CNS, and
molecular mechanisms.
- Roles of brain barriers in etiology of
neurodegenerative diseases such as Parkinson′s syndrome and
Alzheimer′s disease.
- Chelation therapy of metal toxicities.
- Transport of substances by the blood-CSF
barrier in the choroid plexus.
- In vitro model of blood-brain/CSF barrier.
- News on Zheng group research: Science
magazine daily news 06/09/06; Purdue
News Release 03/24/06; Purdue
News Release 06/06/06
Professional
Experiences and Affiliations
- Assistant Professor (1993-1999), Associate
Professor (2000-2002), School of Public Health and College of Physicians
and Surgeons, Columbia University,
New York, NY
- Member of NIH Environmental Health Sciences
Review Committee (2003-2007), Member of NIH/NAL Study Section
(2008-2012)
- Society of Toxicology, Society for
Neuroscience, New
York Academy of Sciences
Book
Published
Selected Publications (from a total of
103)
- Jiang, YM, Mo, XA...Zheng, W (2006). Effective treatment
of manganese-induced occupational Parkinsonism with p-aminosalicylic acid:
A case of 17-year follow-up study. J Occup. Env. Med. 48
(6), 644-649. Video 1 -
Patient with original Treatment Video 2 -
17 year follow-up Download Macromedia Flash Player to view videos.
- Zheng, W, Jiang, YM...Cowan, DM (2009). Chelation
therapy of manganese intoxication with para-aminosalicylic acid (PAS) in
Sprague-Dawley rats. NeuroToxicology
30, 240-248.
- Cowan, DM, Fan, Q...Zheng, W (2009). Manganese
exposure among smelting workers: blood manganese-iron ratio as a novel
tool for manganese exposure assessment. Biomarkers 14 (1), 3-16.
- Cowan, DM, Zheng,
W, Fan, Q (2009). Manganese
exposure among smelting workers: Relationship between blood manganese-iron
ratio and early onset neurobehavioral alterations. NeuroToxicology (in press)
- Choi, BS, Zheng,
W (2009). Copper transport
to the brain by the blood brain barrier and blood-CSF barrier. Brain Res. 1248,
14-21.
- Wang, XQ, Li, GJ, and Zheng, W (2008). Efflux of
Iron from the Cerebrospinal Fluid to the Blood at the Blood-CSF Barrier:
Effect of Manganese Exposure. Exp. Biol Med. 233:1561-1571.
- Wang, XQ, Miller, DS, and Zheng, W (2008). Intracellular
localization and subsequent redistribution of metal transporters in a
rat choroid plexus model following exposure to manganese or iron. Toxicol. Appl. Pharmacol. 230, 167-174.
- Jiang, YM, Long, LL...Zheng, W (2008). Evidence
for altered hippocampal volume and brain metabolites in workers
occupationally exposed to lead: A study by magnetic resonance imaging
and 1H magnetic resonance spectroscopy. Toxicol Letters 181,
118-125.
- Kalia, K, Jiang, W, and Zheng, W (2008). Manganese
accumulates primarily in nuclei of cultured brain cells. NeuroToxicology 29,
466-470.
- Wang, DX, Du, XQ, and Zheng, W (2008). Alteration of saliva and
serum concentrations of manganese, copper, zinc, cadmium and lead among
career welders. Toxicol
Letters 176, 40-47.
- Shi, LZ, Wang, SZ, Li, GJ, and Zheng, W (2008). Use of Z310 Cells as an
In Vitro Blood-Cerebrospinal Fluid Barrier Model: Tight Junction
Proteins and Transport Properties. Toxicology in Vitro 22,
190-199.
- Shi, LZ, and Zheng, W (2007). Early lead exposure
increases the leakage of the blood-cerebrospinal fluid barrier, in
vitro. Human Exp Toxicol 26, 159-167.
- Jiang, Y, Zheng,
W...Pira, E (2007). Brain
Magnetic resonance imaging and manganese concentrations in red blood
cells of smelting workers: search for biomarkers of manganese exposure. NeuroToxicology
28, 126-135.
- Crossgrove, JS, Smith, EL, and Zheng, W (2007). Macromolecules
involved in production and metabolism of beta-amyloid at the brain
barriers. Brain Res. 1138, 187-195.
- Wang, X, Li, GJ, and Zheng, W (2006). Up
regulation of DMT1 expression in choroidal epithelia of the blood-CSF
barrier following manganese exposure in vivo. Brain Res. 1097,
1-10.
- Li, GJ, Choi, BS, Wang, X, Liu, J, Waalkes, MP,
and Zheng, W (2006). Molecular Mechanism
of distorted iron regulation in the blood-CSF barrier and regional
blood-brain barrier following in vivo subchronic manganese exposure.
NeuroToxicology 27, 737-744.
- Jiang, Y, and Zheng, W (2005). Cardiovascular
toxicities upon manganese exposure. Cardiovasc. Toxicol. 5:345-354.
- Crossgrove, JS, Li, GJ, and Zheng, W (2005). The choroid plexus
removes beta-amyloid from the cerebrospinal fluid. Exp Biol Med 230(10), 771-776.
- Shi, LZ and Zheng, W (2005). Establishment of an In
Vitro Brain Barrier Epithelial Transport System for Pharmacological and
Toxicological Study. Brain
Res. 1057, 37-48.
- Lu, L, Zhang, L-L, Li, GJ, Guo, W, Liang, W,
and Zheng, W (2005). Serum
concentrations of manganese and iron as the potential biomarkers for
manganese exposure in welders. NeuroToxicology 26,
257-265.
- Li, GJ, Zhao, Q, and Zheng, W (2005). Alteration
at translational but not transcriptional level of transferrin receptor
expression following manganese exposure at the blood-CSF barrier in
vitro. Toxicol. Appl. Pharmacol. 205,
188-200.
- Crossgrove, JS, and Zheng, W (2004). Manganese toxicity upon
overexposure. NMR in
Biomedicine 17, 544-553.
- Zheng, W (2004). Introduction
to the blood-CSF barrier. In: The
Blood-Cerebrospinal Barrier, Zheng W and Chodobski A, Ed., CRC
Press, New York.
- Li, GJ, and Zheng, W (2004). Regulation of neuroactive
metals by the choroid plexus. In: The Blood-Cerebrospinal Barrier,
Zheng W and Chodobski A, Ed., CRC Press, New York. pp211-239.
- Zheng, W, and Segal, MB (2004). In situ techniques
used in the blood-CSF barrier research. In: The Blood-Cerebrospinal
Barrier, Zheng W and Chodobski A, Ed., CRC Press, New York. pp541-551.
- Deane, R, Zheng,
W, and Zlokovic, BV (2004). Brain capillary
endothelium and choroid plexus epithelium regulate transport of
transferrin-bound and free iron into the rat brain. J. Neurochem. 88, 813-820.
- Li, GJ, Zhang, L, Lu, L, Wu, P, and Zheng, W (2004). Occupational exposure to welding
fume among welders: alterations of manganese, iron, zinc, copper, and
lead in body fluids and the oxidative stress status. J. Occup. Environ. Med. 46, 241-248.
- Zheng, W,
Aschner, M, and Ghersi-Egea J (2003). Brain barrier systems: a new frontier
in metal neurotoxicological research. Toxicol. Appl.
Pharmacol. 192, 1-11.
- Zheng, W,
Deane, R, Redzic, Z, Preston, JE, and Segal, MB (2003). Transport of L-[125I]Thyroxine by
in-situ perfused ovine choroid plexus: Inhibition by Lead Exposure. J.
Toxicol. Env. Health. 66, 435-451.
- Zheng, W,
and Zhao, Q (2002). Establishment
and characterization of an immortalized Z310 choroidal epithelial cell
line from murine choroid plexus. Brain Res. 958, 371-380.
- Louis, ED, Zheng, W, Jurewicz, EC,
Watner, D, Chen, J, Factor-Litvak, P, and Parides, M (2002). Elevation of blood
beta-carboline alkaloids in essential tremor. Neurology
59, 1940-1944.
- Zheng, W,
and Zhao, Q (2002). Blood-CSF barrier in culture: Development of primary
culture and transepithelial transport model from choroidal epithelial
cells. Methods Mol. Biol. 188, 99-114.
- Zheng, W
(2001). Neurotoxicology of
the brain barrier system: New implications. J.
Toxicol. Clin. Toxicol. 39,
711-719.
- Chen, JY, Tsao, G, and Zhao, Q, and Zheng, W
(2001). Differential
cytotoxicity of Mn(II) and Mn(III): special reference to mitochondrial
[Fe-S] containing enzymes. Toxicol. Appl. Pharmacol. 175, 160-168.
- Guan, Y, Louis, ED, and Zheng, W (2001).
Toxicokinetics of tremorogenic
natural products, harmane and harmine in male Sprague-Dawley rats.
J. Toxicol. Env. Health 64, 645-660.
- Zheng, W,
and Zhao, Q (2001). Iron
overload following manganese exposure in cultured neuronal, but not
neuroglial cells. Brain Res. 897, 175-179.
- Zheng, W,
Lu, YM, Lu, GY, Zhao, Q, Cheung, O, and Blaner, WS (2001). Transthyretin, thyroxin, and
retinol-binding protein in human cerebrospinal fluid: Effect of
lead exposure. Toxicol. Sci. 61, 107-114.
- Zheng, W,
Kim, H, and Zhao, Q (2000). Comparative
toxicokinetics of manganese chloride and methylcyclo-pentadienyl Mn
tricarbonyl in male Sprague-Dawley rats. Toxicol.
Sci. 54, 295-301.
- Zheng, W,
Blaner, WS, and Zhao, Q (1999). Inhibition by Pb of production and
secretion of transthyretin in the choroid plexus: Its relationship to
thyroxine transport at the blood-CSF barrier. Toxicol. Appl.
Pharmacol. 155, 24-31.
- Zheng, W,
Zhao, Q, Slavkovich, V, Aschner, M, and, Graziano, H (1999). Alteration of iron homeostasis
following chronic exposure to manganese in rats. Brain Res.
833, 125-132.
- Zhao, Q, Slavkovich, V, and, Zheng, W
(1998). Lead exposure
promotes translocation of protein kinase C activity in rat choroid
plexus in vitro, but not in vivo. Toxicol. Appl. Pharmacol.
149, 99-106.
- Zheng, W,
Ren, S, and Graziano, JH (1998). Manganese inhibits mitochondrial
aconitase: A mechanism of manganese neurotoxicity. Brain Res.
799, 334-342.
- Zheng, W,
Shen, H, Blaner, WS, Zhao, Q, Ren, X, and Graziano, JH (1996). Chronic lead exposure alters
transthyretin concentration in rat cerebrospinal fluid: The role
of the choroid plexus. Toxicol. Appl. Pharmacol.
139, 445-450.
- Zheng, W, Perry, DF, Nelson, DL, and Aposhian, HV
(1991). Protection of cerebrospinal fluid against toxic metals by the
choroid plexus. FASEB J. 5, 2188-2193.
- Zheng, W, Maiorino, RM, Brendel, K, and Aposhian, HV
(1990). Determination and metabolism of dithiol chelating agents: VII.
Biliary excretion of dithiols and their interactions with cadmium and
metallothionein. Fundam. Appl.
Toxicol. 14, 598-607.
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